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MT-2 10 mg lyophilised research vial

Melanocortin Research

MT-2

MT-2 10 mg is a cyclic lactam heptapeptide analogue of the alpha-MSH 4-10 region, supplied as a lyophilised research peptide; lot PS07-MT210 tested by ILS Laboratories shows 99.68% HPLC purity.

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99.68% HPLC purity  ·  Lot report published

For laboratory research use only. Not for human or veterinary use. Not a drug, dietary supplement, or cosmetic. Not evaluated by the FDA.

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CHEMICAL BLOCK

The data your lab notebook needs.

Identity data for this material. Published lot reports, where one exists, are in the lab report library.

FORM Lyophilized Powder
CAS NUMBER 121062-08-6
MOLECULAR FORMULA C50H69N15O9
MOLECULAR WEIGHT 1024.2 g/mol
PURITY Per lot (see published lab report)
STORAGE Lyophilized (powder): −20°C, away from light, unopened

COMMON QUESTIONS

Everything researchers ask before ordering.

MT-2 is a synthetic cyclic lactam peptide amide (N-acetylated), sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.

Formula C50H69N15O9, molecular weight ~1024.2 g/mol, CAS 121062-08-6.

Yes. A report for lot PS07-MT210, from ILS Laboratories, San Diego, CA, lists 99.68% HPLC purity and 10.6 mg net content. Published reports are at vortexresearch.net/coa/.

Orders placed before 2pm EST ship same day. Standard ground delivery takes 2–4 business days within the continental US. Expedited options are available at checkout.

Each order includes the research material. Where a report is published for the stocked lot, it is linked on this page and listed at vortexresearch.net/coa/.

Tested lots are reported by independent labs (ILS Laboratories and Freedom Diagnostics). Each published report names the lab, the lot, the test date and every assay run, including purity by HPLC and identity by HPLC or LC-MS. All reports are listed at vortexresearch.net/coa/.

Store lyophilized powder at −20°C, away from light, until use.

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All sales are final. If your order arrives damaged or incorrect, contact us within 7 days of delivery and we'll make it right.

No. All products sold by Vortex Research are designated for in vitro laboratory research use only by qualified professionals. They are not approved for human or veterinary use.

Compound information

MT-2 (Melanotan II) research data.

Cyclic lactam heptapeptide analogue of the α-MSH 4-10 region

MT-2 (Melanotan II, MT-II) is a synthetic cyclic heptapeptide amide, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. It is a shortened analogue of the 4-10 region of the melanocortin peptide α-MSH, in which a lactam bridge joins the side chains of aspartic acid and lysine to close a 23-membered ring. It was designed in 1989 by Al-Obeidi, Hruby and colleagues from the linear [Nle4, D-Phe7]-α-MSH template using molecular-dynamics modelling.

Published work is concentrated in peptide chemistry and receptor pharmacology: radioligand-binding and selectivity studies at the human MC1, MC3, MC4 and MC5 receptor subtypes expressed in cell lines, structure-activity series that modify single positions of the ring, and newer cyclisation chemistries such as triazole-bridged analogues. MT-2 is also the parent template of several later receptor-selective research ligands.

TypeSynthetic cyclic lactam peptide amide (N-acetylated)
Also listed asMelanotan II, Melanotan 2, MT2
SequenceAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
Residues7
FormulaC50H69N15O9
Molecular weight~1024.2 g/mol
CAS121062-08-6
PubChem CID92432

Lab reports

Lot reports for this product.

Each report names the lab, the lot, the test date and every assay run. Verify it on the lab's own portal.

10 mg · Lot PS07-MT21099.68% purity (HPLC)
LabILS Laboratories, San Diego, CA
Report typePartner-facility report on the same batch Vortex stocks
Tested08/11/2026
Net content10.6 mg
COA numberCOA-2026-2VPSU4
Access codeBXPYLQ35

Assays: Purity (HPLC), Identity (HPLC), Net content, Heavy metals (ICP-MS), Sterility (PCR), Endotoxin (USP <85>), Fentanyl screen

Verify at the lab →

All published reports: lab report library →

Sources & references

Published literature.

Peer-reviewed papers on MT-2 (Melanotan II), linked to PubMed.

  1. Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
    Al-Obeidi F, Castrucci AM, Hadley ME, et al.. J Med Chem (1989). PubMed 2555512 →
  2. Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes.
    Schiöth HB, Müceniece R, Mutulis F, et al.. Peptides (1997). PubMed 9357059 →
  3. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
    Grieco P, Cai M, Han G, et al.. Peptides (2007). PubMed 17482720 →
  4. 1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.
    Testa C, Scrima M, Grimaldi M, et al.. J Med Chem (2014). PubMed 25347033 →

For in-vitro laboratory research use only by qualified researchers. Not for human or veterinary consumption. Not a drug, dietary supplement or cosmetic. These statements have not been evaluated by the FDA, and this product is not intended to diagnose, treat, cure or prevent any disease. This site does not provide medical advice. Literature listed above describes published research and is not a claim about this product. By purchasing, the buyer confirms the material is for laboratory research conducted by qualified personnel.

Research library

Further reading.

Identity, analysis and storage references from the Vortex research library.

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