Melanocortin Research
MT-1
MT-1 is a linear 13-residue alpha-MSH analogue (CAS 75921-69-6), supplied as a lyophilised research peptide.
Lot report pending · Lab report library
MASS
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CHEMICAL BLOCK
The data your lab notebook needs.
Identity data for this material. Published lot reports, where one exists, are in the lab report library.
| FORM | Lyophilized Powder |
|---|---|
| CAS NUMBER | 75921-69-6 |
| SEQUENCE | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| MOLECULAR FORMULA | C78H111N21O19 |
| MOLECULAR WEIGHT | 1646.8 g/mol |
| PURITY | Per lot (see published lab report) |
| STORAGE | Lyophilized (powder): −20°C, away from light, unopened |
COMMON QUESTIONS
Everything researchers ask before ordering.
Compound information
MT-1 (afamelanotide) research data.
[Nle4, D-Phe7]-α-MSH: a linear 13-residue melanocortin peptide analogue
MT-1, also known as Melanotan I, NDP-MSH or [Nle4, D-Phe7]-α-MSH, carries the INN afamelanotide. It is a linear, N-acetylated 13-residue peptide amide that differs from the native melanocortin peptide α-MSH at two positions: norleucine replaces methionine 4, and D-phenylalanine replaces L-phenylalanine 7. The analogue was first described in 1980 by Sawyer, Hruby, Hadley and colleagues at the University of Arizona.
Published work spans peptide synthesis and structure-activity chemistry, radioligand-binding studies at cloned melanocortin receptor subtypes expressed in cell lines, and analogue design. A radioiodinated form of the peptide is a common reference ligand in melanocortin receptor-binding assays, and its sequence served as the template for later analogues, including the cyclic lactam series that produced MT-II.
| Type | Synthetic linear peptide amide (N-acetylated) |
|---|---|
| Also listed as | Melanotan I, Melanotan 1, MT1 |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Residues | 13 |
| Formula | C78H111N21O19 |
| Molecular weight | ~1646.8 g/mol |
| CAS | 75921-69-6 |
| PubChem CID | 16197727 |
Lab reports
Lot reports for this product.
Each report names the lab, the lot, the test date and every assay run. Verify it on the lab's own portal.
No lot report is published for this product yet. Reports are added to the lab report library as testing completes.
Sources & references
Published literature.
Peer-reviewed papers on MT-1 (afamelanotide), linked to PubMed.
- Characterisation of melanocortin receptor subtypes by radioligand binding analysis.
Schiöth HB, Muceniece R, Wikberg JE, et al.. Eur J Pharmacol (1995). PubMed 7774675 → - Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity.
Joseph CG, Wilczynski A, Holder JR, et al.. Peptides (2003). PubMed 15127941 → - Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
Al-Obeidi F, Castrucci AM, Hadley ME, et al.. J Med Chem (1989). PubMed 2555512 →
For in-vitro laboratory research use only by qualified researchers. Not for human or veterinary consumption. Not a drug, dietary supplement or cosmetic. These statements have not been evaluated by the FDA, and this product is not intended to diagnose, treat, cure or prevent any disease. This site does not provide medical advice. Literature listed above describes published research and is not a claim about this product. By purchasing, the buyer confirms the material is for laboratory research conducted by qualified personnel.
Research library
Further reading.
Identity, analysis and storage references from the Vortex research library.
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