| Mass | 10MG |
|---|
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Melanocortin Research
MT-2 Spray
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Original price was: $69.99.$59.99Current price is: $59.99.
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CHEMICAL BLOCK
The data your lab notebook needs.
Pulled from the verification packet included with each shipment. Cross-check the batch ID on your vial against the CoA.
| FORM | Lyophilized Powder |
|---|---|
| CAS NUMBER | 121062-08-6 |
| MOLECULAR FORMULA | C50H69N15O9 |
| MOLECULAR WEIGHT | 1024.2 g/mol |
| PURITY | Per lot (see published lab report) |
| STORAGE | Lyophilized (powder): −20°C, away from light, unopened |
COMMON QUESTIONS
Everything researchers ask before ordering.
Compound information
MT-2 (Melanotan II) research data.
Cyclic lactam heptapeptide analogue of the α-MSH 4-10 region
MT-2 (Melanotan II, MT-II) is a synthetic cyclic heptapeptide amide, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. It is a shortened analogue of the 4-10 region of the melanocortin peptide α-MSH, in which a lactam bridge joins the side chains of aspartic acid and lysine to close a 23-membered ring. It was designed in 1989 by Al-Obeidi, Hruby and colleagues from the linear [Nle4, D-Phe7]-α-MSH template using molecular-dynamics modelling.
Published work is concentrated in peptide chemistry and receptor pharmacology: radioligand-binding and selectivity studies at the human MC1, MC3, MC4 and MC5 receptor subtypes expressed in cell lines, structure-activity series that modify single positions of the ring, and newer cyclisation chemistries such as triazole-bridged analogues. MT-2 is also the parent template of several later receptor-selective research ligands.
| Type | Synthetic cyclic lactam peptide amide (N-acetylated) |
|---|---|
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Residues | 7 |
| Formula | C50H69N15O9 |
| Molecular weight | ~1024.2 g/mol |
| CAS | 121062-08-6 |
| PubChem CID | 92432 |
Lab reports
Lot reports for this product.
Each report names the lab, the lot, the test date and every assay run. Verify it on the lab's own portal.
No lot report is published for this product yet. Reports are added to the lab report library as testing completes.
Sources & references
Published literature.
Peer-reviewed papers on MT-2 (Melanotan II), linked to PubMed.
- Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
Al-Obeidi F, Castrucci AM, Hadley ME, et al.. J Med Chem (1989). PubMed 2555512 → - Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes.
Schiöth HB, Müceniece R, Mutulis F, et al.. Peptides (1997). PubMed 9357059 → - Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Grieco P, Cai M, Han G, et al.. Peptides (2007). PubMed 17482720 → - 1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.
Testa C, Scrima M, Grimaldi M, et al.. J Med Chem (2014). PubMed 25347033 →
For in-vitro laboratory research use only by qualified researchers. Not for human or veterinary consumption. Not a drug, dietary supplement or cosmetic. These statements have not been evaluated by the FDA, and this product is not intended to diagnose, treat, cure or prevent any disease. This site does not provide medical advice. Literature listed above describes published research and is not a claim about this product. By purchasing, the buyer confirms the material is for laboratory research conducted by qualified personnel.
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