Specialty Compounds

MOTS-C

Name: MOTS-C
Brand: Vortex Research
SKU: VR-20553
Price: 49.99 USD
Availability: InStock

MOTS-c peptide 10 mg is a 16-residue peptide encoded in the mitochondrial 12S rRNA gene, supplied as a lyophilised research material, with its lot report published on this page.

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99.94% HPLC purity · Lot report published

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Category: Specialty Compounds

CHEMICAL BLOCK

The data your lab notebook needs.

Identity data for this material. Published lot reports, where one exists, are in the lab report library.

FORM	Lyophilized Powder
CAS NUMBER	1627580-64-6
MOLECULAR FORMULA	C101H152N28O22S2
MOLECULAR WEIGHT	2174.62 g/mol
PURITY	Per lot (see published lab report)
STORAGE	Lyophilized (powder): −20°C, away from light, unopened

COMMON QUESTIONS

Everything researchers ask before ordering.

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-residue peptide, Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR). Its formula is C101H152N28O22S2, its mass is about 2174.6 g/mol and its CAS number is 1627580-64-6. It was first described in 2015 by Changhan Lee and colleagues at the University of Southern California.

Its sequence is encoded by a short open reading frame in the mitochondrial 12S rRNA gene rather than in the nuclear genome, which is why it is grouped with humanin as a mitochondrial-derived peptide. The material supplied here is made by chemical synthesis, with a free C-terminal acid.

ILS Laboratories (San Diego, CA) tested this lot for Vortex Research on 06/24/2026. The report covers purity and identity by HPLC, net content (10.5 mg measured against the 10 mg label), heavy metals by ICP-MS, sterility by PCR and endotoxin (USP 85).

Look the report up on the ILS portal, portal.ils-lab.com, with access code FUYJ3PQF (COA number COA-2026-956871).

Orders placed before 2pm EST ship same day. Standard ground delivery takes 2–4 business days within the continental US. Expedited options are available at checkout.

Each order includes the research material. Where a report is published for the stocked lot, it is linked on this page and listed at vortexresearch.net/coa/.

Tested lots are reported by independent labs (ILS Laboratories and Freedom Diagnostics). Each published report names the lab, the lot, the test date and every assay run, including purity by HPLC and identity by HPLC or LC-MS. All reports are listed at vortexresearch.net/coa/.

Store lyophilized powder at −20°C, away from light, until use.

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No. All products sold by Vortex Research are designated for in vitro laboratory research use only by qualified professionals. They are not approved for human or veterinary use.

Additional information

Mass	10MG

Compound information

MOTS-C research data.

16-residue peptide encoded by a short open reading frame in the 12S rRNA gene

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-residue peptide, Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. Its sequence is encoded by a short open reading frame in mitochondrial DNA rather than in the nuclear genome. It was first described in 2015 by Changhan Lee and colleagues at the University of Southern California. The material supplied here is a synthetic peptide with a free C-terminal acid.

MOTS-c is grouped with humanin as a peptide encoded outside the nuclear genome. Published work spans its genomic origin and nomenclature, peptide chemistry, cell-line studies of where the peptide localizes, rodent pharmacology and analytical method papers. The references below are limited to reviews of its encoding and nuclear-localization literature.

Type	Synthetic peptide (mitochondrial-derived peptide sequence)
Also listed as	MOTSc, MOTS c
Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
Residues	16
Formula	C101H152N28O22S2
Molecular weight	~2174.6 g/mol
CAS	1627580-64-6
PubChem CID	146675088

Lab reports

Lot reports for this product.

Each report names the lab, the lot, the test date and every assay run. Verify it on the lab's own portal.

10 mg · Lot Purple cap99.94% purity (HPLC)

Lab	ILS Laboratories, San Diego, CA
Report type	Tested for Vortex Research
Tested	06/24/2026
Net content	10.5 mg
COA number	COA-2026-956871
Access code	FUYJ3PQF

Assays: Purity (HPLC), Identity (HPLC), Net content, Heavy metals (ICP-MS), Sterility (PCR), Endotoxin (USP <85>)

Verify at the lab →

All published reports: lab report library →

Sources & references

Published literature.

Peer-reviewed papers on MOTS-C, linked to PubMed.

MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.
Benayoun BA, Lee C. Bioessays (2019). PubMed 31378979 →
Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.
Lee C. Mol Cell Oncol (2019). PubMed 31131297 →

For in-vitro laboratory research use only by qualified researchers. Not for human or veterinary consumption. Not a drug, dietary supplement or cosmetic. These statements have not been evaluated by the FDA, and this product is not intended to diagnose, treat, cure or prevent any disease. This site does not provide medical advice. Literature listed above describes published research and is not a claim about this product. By purchasing, the buyer confirms the material is for laboratory research conducted by qualified personnel.

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