| Mass | 10MG |
|---|
Specialty Compounds
SS-31
SS-31 peptide 10 mg is the aromatic-cationic tetrapeptide D-Arg-Dmt-Lys-Phe-NH2 (CAS 736992-21-5), supplied as a lyophilised research material.
Lot report pending · Lab report library
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CHEMICAL BLOCK
The data your lab notebook needs.
Identity data for this material. Published lot reports, where one exists, are in the lab report library.
| FORM | Lyophilized Powder |
|---|---|
| PURITY | Per lot (see published lab report) |
| STORAGE | Lyophilized (powder): −20°C, away from light, unopened |
COMMON QUESTIONS
Everything researchers ask before ordering.
Compound information
SS-31 research data.
Aromatic-cationic tetrapeptide D-Arg-Dmt-Lys-Phe-NH2 (elamipretide)
SS-31 is a synthetic tetrapeptide, D-Arg-Dmt-Lys-Phe-NH2, where Dmt is 2',6'-dimethyl-L-tyrosine. It carries alternating cationic and aromatic residues, a D-amino acid at position one and a C-terminal amide. The compound is one of the Szeto-Schiller (SS) peptides designed by Hazel Szeto and Peter Schiller. Its nonproprietary name is elamipretide, and it was earlier known by the development codes Bendavia and MTP-131.
SS-31 is classed as a cell-permeable aromatic-cationic peptide. Published work spans structure-activity comparisons across related tetrapeptides, lipid-bilayer binding biophysics, protein-interaction mapping by cross-linking mass spectrometry, and molecular-dynamics simulation. The references below are limited to these chemistry and biophysics papers.
| Type | Synthetic tetrapeptide amide |
|---|---|
| Also listed as | SS31 |
| Sequence | D-Arg-Dmt-Lys-Phe-NH2 (Dmt = 2',6'-dimethyl-L-tyrosine) |
| Residues | 4 |
| Other names | Elamipretide; Bendavia; MTP-131 |
| Formula | C32H49N9O5 |
| Molecular weight | ~639.8 g/mol (free base) |
| CAS | 736992-21-5 |
| PubChem CID | 11764719 |
Lab reports
Lot reports for this product.
Each report names the lab, the lot, the test date and every assay run. Verify it on the lab's own portal.
No lot report is published for this product yet. Reports are added to the lab report library as testing completes.
Sources & references
Published literature.
Peer-reviewed papers on SS-31, linked to PubMed.
- Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds.
Mitchell W, Tamucci JD, Ng EL, et al.. Elife (2022). PubMed 35913044 → - The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action.
Mitchell W, Ng EA, Tamucci JD, et al.. J Biol Chem (2020). PubMed 32273339 → - Mitochondrial protein interaction landscape of SS-31.
Chavez JD, Tang X, Campbell MD, et al.. Proc Natl Acad Sci U S A (2020). PubMed 32554501 → - Peptide Power: Mechanistic Insights into the Effect of Mitochondria-Targeted Tetrapeptides on Membrane Electrostatics from Molecular Simulations.
Tamucci JD, Alder NN, May ER. Mol Pharm (2023). PubMed 37904323 →
For in-vitro laboratory research use only by qualified researchers. Not for human or veterinary consumption. Not a drug, dietary supplement or cosmetic. These statements have not been evaluated by the FDA, and this product is not intended to diagnose, treat, cure or prevent any disease. This site does not provide medical advice. Literature listed above describes published research and is not a claim about this product. By purchasing, the buyer confirms the material is for laboratory research conducted by qualified personnel.
Research library
Further reading.
Identity, analysis and storage references from the Vortex research library.
